Publications

  1. Kam-Hansen S, Jakubowski M, Kelley JM, Kirsch I, Hoaglin DC, Kaptchuk TJ, Burstein R.  Altered placebo and drug labeling changes the outcome of episodic migraine attacks. Sci. Transl. Med. 6, 218ra5 (2014)
  2. Kelley JM, Kraft-Todd G, Schapira L, Kossowsky J, Riess H. The Influence of the Patient-Clinician Relationship on Healthcare Outcomes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS ONE 9(4): e94207 (2014)
  3. White Paper: “Placebo Effects in Guidelines, Practice, and Patient Choice: Beginning a Conversation about an Under-recognized Therapeutic Tool”  March 2014.
  4. Hashmi JA, Kong J, Spaeth R, Khan S, Kaptchuk TJ, Gollub RL. Functional network architecture predicts psychologically mediated analgesia related to treatment in chronic pain patients.  J Neurosci. 2014 Mar 12;34(11):3924-36.

  5. Yu R, Gollub RL, Vangel M, Kaptchuk T, Smoller JW, Kong J.  Placebo analgesia and reward processing: Integrating genetics, personality, and intrinsic brain activity.  Hum Brain Mapp. 2014 Feb 27.
  6. Jensen KB, Petrovic P, Kerr C, Kirsch I, Raicek J, Cheetham A, Spaeth R, Cook A, Gollub RL, Kong J, Kaptchuk TJ.  Sharing pain and relief: neural correlates of physicians during treatment of patients.  Mol Psych 2013
  7. Kirsch I. The placebo effect revisited: Lessons learned to date. Complement Ther Med (2013)
  8. Raicek J, Stone BH, Kaptchuk TJ. Placebos in 19th century medicine: a quantitative analysis of the BMJ.  BMJ 2012: 345:38326
  9. Hall KT, Lembo AJ, Kirsch I, Ziogas DC, Douaiher J, et al.  Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome. PLoS One 2012; 7: e48135.
  10. Jensen KB, Kaptchuk TJ, Kirsch I, Raicek J, Lindstrome KM,  Berna C, Gollub RL, Ingvare M, and Kong J.  Nonconscious activation of placebo and nocebo responses.  PNAS 2012: 109: 15959-64
  11. Kelley JM, Kaptchuk TJ, Cusin C, Lipkin S, Fava M. Open-label placebo for Major Depressive Disorder: a pilot ramdomized controlled trial. Psychother Psychosom 2012;81:312-314
  12. Robert B. Michael, Maryanne Garry, and Irving Kirsch. Suggestion, Cognition, and Behavior. Current Directions in Psychological Science 2012; 21 (3): 151-156.
  13. Wells, R, Kaptchuk TJ. To Tell the Truth, the Whole Truth, May Do Patients Harm: The Problem of the Nocebo Effect for Informed Consent. The American Journal of Bioethics 2012; 12(3): 22–29.
  14. Bishop FL, Jacobson EE, Shaw J, Kaptchuk TJ.  Scientific tools, fake treatments or triggers for psychological healing: How RCT participants conceptualize placebos.  Soc Sci Med 2012.
  15. Bishop FL, Jacobson EE, Shaw J, Kaptchuk TJ.  Debriefing to placebo allocation: A phenomenological sudy of participants’ experiences in a randomized controlled trial. Qualitative Hlth Res Aug 2012.
  16. Kerr CE, Shaw JR, Conboy LA, Kelley JM, Jacobson E, Kaptchuk TJ.  Placebo acupuncture as a form of ritual touch: a neurophenomenological study.  Consciousness Cognition 2011; (in press).
  17. Hróbjartsson A, Kaptchuk TJ, Miller FG. Placebo effect studies are susceptible to response bias and other types biases.  J Clin Epidemiol 2011; (in press).
  18. Grelotti D, Kaptchuk TJ. Placebo by proxy: Clinicians’ and family members’ feeling and perceptions about a treatment may influence their judgments about its effectiveness. BMJ 2011; 343:d4345: 1-2.
  19. Wechsler ME, Kelley JM, Boyd IO, Dutile S, Marigowda G, Kirsch I, Israel E, Kaptchuk TJ. Active albuterol or placebo, sham acupuncture, or no intervention in asthma. N Engl J Med. 2011 Jul 14; 365 (2) :119-26.
  20. Kaptchuk TJ.  Placebo studies and ritual theory: A comparative analysis of Navajo, acupuncture and biomedical healing.  Phil Trans Roy Soc B; 2011; 366:1846-58.
  21. Berna C., Cojan Y., Vuilleumier P., Desmeules J. How neuroscience has helped our understanding of placebo analgesia (French), Revue Médicale Suisse, 2011; 7: 1390-3.
  22. Kaptchuk TJ, Friedlander E, Kelley JM, Sanchez MN, Kokkotou E, Singer JP, Kowalczykowski M, Miller FG, Kirsch I, Lembo AJ.   Placebo without deception: a randomized controlled trial in irritable bowel syndrome.  PLoS One 2010; 5:e15591.
  23. Kelley JM, Kaptchuk TJ. Group analysis versus individual response: the inferential limits of randomized controlled trials. Contemp Clin Trials. 2010 Sep; 31 (5) :423-8.
  24. Takakura N, Takayama M, Kawase A, Kaptchuk TJ, Yajima H. Double blinding with a new placebo needle: a further validation study. Acupunct Med. 2010 Sep; 28 (3) :144-8.
  25. Cremonini F, Ziogas DC, Chang HY, Kokkotou E, Kelley JM, Conboy L, Kaptchuk TJ, Lembo AJ. Meta-analysis: the effects of placebo treatment on gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2010 Jul; 32 (1) :29-42.
  26. Wasan AD, Kong J, Pham LD, Kaptchuk TJ, Edwards RR, Gollub RL.  The impact of placebo, psychopathology, and expectations on the response to acupuncture needling in patients with  chronic low back pain.  J Pain 2010; 11: 555-63.
  27. Napadow V, LaCount L, Park K, As-Sanie S, Clauw DJ, Harris RE. Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity. Arthritis & Rheumatism. 2010. 62(8):2545-55.
  28. Berna C., Leknes S., Holmes E.A., Edwards R.R., Goodwin G.M., Tracey I. Induction of depressed mood disrupts emotion regulation neurocircuitry and enhances pain unpleasantness. Biological Psychiatry, 2010; 67 (11):1083-90
  29. Roscoe JA, O’Neill M, Jean-Pierre P, Heckler CE, Kaptchuk TJ, Bushunow P, Shayne M, Huston A, Qazi R, Smith B. An exploratory study on the effects of an expectancy manipulation on chemotherapy-related nausea. J Pain Symptom Manage. 2010 Sep; 40 (3) :379-90.
  30. Kokkotou E, Conboy LA, Ziogas DC, Quilty MT, Kelley JM, Davis RB, Lembo AJ, Kaptchuk TJ. Serum correlates of the placebo effect in irritable bowel syndrome. Neurogastroenterol Motil. 2010 Mar; 22 (3) :285-e81.
  31. Mazzoni, G., Foan, L., Hyland, M. E., & Kirsch, I. The effects of observation and gender on psychogenic symptoms. Health Psychology, 2010; 29(2), 181-185.
  32. Finniss DG, Kaptchuk TJ, Miller F, Benedetti F. Biological, clinical, and ethical advances of placebo effects. Lancet. 2010 Feb 20; 375 (9715) :686-95.
  33. Fregni F, Imamura M, Chien HF, Lew HL, Boggio P, Kaptchuk TJ, Riberto M, Hsing WT, Battistella LR, Furlan A, International placebo symposium working group. Challenges and recommendations for placebo controls in randomized trials in physical and rehabilitation medicine: a report of the international placebo symposium working group. Am J Phys Med Rehabil. 2010 Feb; 89 (2) :160-72.
  34. Conboy LA, Macklin E, Kelley J, Kokkotou E, Lembo A, Kaptchuk T. Which patients improve: characteristics increasing sensitivity to a supportive patient-practitioner relationship. Soc Sci Med. 2010 Feb; 70 (3) :479-84.
  35. Kaptchuk TJ, Kerr CE, Zanger A. Placebo controls, exorcisms, and the devil. Lancet. 2009 Oct 10; 374 (9697) :1234-5.
  36. Miller FG, Colloca L, Kaptchuk TJ. The placebo effect: illness and interpersonal healing. Perspect Biol Med. 2009 Autumn; 52 (4) :518-39.
  37. Kelley JM, Lembo AJ, Ablon JS, Villanueva JJ, Conboy LA, Levy R, Marci CD, Kerr CE, Kirsch I, Jacobson EE, Riess H, Kaptchuk TJ. Patient and practitioner influences on the placebo effect in irritable bowel syndrome. Psychosom Med. 2009 Sep; 71 (7) :789-97.
  38. Kaptchuk TJ, Shaw J, Kerr CE, Conboy LA, Kelley JM, Csordas TJ, Lembo AJ, Jacobson EE. “Maybe I made up the whole thing”: placebos and patients’ experiences in a randomized controlled trial. Cult Med Psychiatry. 2009 Sep; 33 (3) :382-411.
  39. Kong J, Kaptchuk TJ, Polich G, Kirsch I, Vangel M, Zyloney C, Rosen B, Gollub RL. An fMRI study on the interaction and dissociation between expectation of pain relief and acupuncture treatment. Neuroimage. 2009 Sep; 47 (3) :1066-76.
  40. Jensen KB, Lonsdorf TB, Schalling M, Kosek E, Ingvar M. Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val(158)met polymorphism. PLoS One. 2009 Jun 23;4(6):e6016.
  41. Brunoni AR, Lopes M, Kaptchuk TJ. Fregni F.  Placebo effects in Major Depressive Disorder: a systematic review and meta-analysis comparing a non-pharmacological vs. a pharmacological intervention.  PLoS One 2009; 4:e4824.
  42. Kelley JM, Boulos PR, Rubin PA, Kaptchuk TJ. Mirror, mirror on the wall: placebo effects that exist only in the eye of the beholder. J Eval Clin Pract. 2009 Apr; 15 (2) :292-8.
  43. Passos MC, Lembo AJ, Conboy LA, Kaptchuk TJ, Kelly JM, Quilty MT, Kerr CE, Jacobson EE, Hu R, Friedlander E, Drossman DA. Adequate relief in a treatment trial with IBS patients: a prospective assessment. Am J Gastroenterol. 2009 Apr; 104 (4) :912-9.
  44. Bertisch SM, Legedza AR, Phillips RS, Davis RB, Stason WB, Goldman RH, Kaptchuk TJ. The impact of psychological factors on placebo responses in a randomized controlled trial comparing sham device to dummy pill. J Eval Clin Pract. 2009 Feb; 15 (1) :14-9.
  45. Brunoni AR, Lopes M, Kaptchuk TJ, Fregni F. Placebo response of non-pharmacological and pharmacological trials in major depression: a systematic review and meta-analysis. PLoS One. 2009; 4 (3) :e4824.
  46. Kong J, Kaptchuk TJ, Webb JM, Kong JT, Sasaki Y, Polich GR, Vangel MG, Kwong K, Rosen B, Gollub RL. Functional neuroanatomical investigation of vision-related acupuncture point specificity–a multisession fMRI study. Hum Brain Mapp. 2009 Jan; 30 (1) :38-46.
  47. Kaptchuk TJ, Kelley JM, Conboy LA, Davis RB, Kerr CE, Jacobson EE, Kirsch I, Schyner RN, Nam BY, Nguyen LT, Park M, Rivers AL, McManus C, Kokkotou E, Drossman DA, Goldman P, Lembo AJ. Components of the placebo effect: a randomized controlled trial in irritable bowel syndrome. BMJ 2008; 336:998-1003.
  48. Kong J, Gollub RL, Polich G, Kirsch I, Laviolette P, Vangel M, Rosen B, Kaptchuk TJ. A functional magnetic resonance imaging study on the neural mechanisms of hyperalgesic nocebo effect. J Neurosci. 2008 Dec 3; 28 (49) :13354-62.
  49. Tilburt JC, Emanuel EJ, Kaptchuk TJ, Curlin FA, Miller FG. Prescribing “placebo treatments”: results of national survey of US internists and rheumatologists. BMJ. 2008 Oct 23; 337:a1938.
  50. Kaptchuk TJ, Kelley JM, Deykin A, Wayne PM, Lasagna LC, Epstein IO, Kirsch I, Wechsler ME. Do “placebo responders” exist?. Contemp Clin Trials. 2008 Jul; 29 (4) :587-95.
  51. Miller FG, Kaptchuk TJ. Deception of subjects in neuroscience: an ethical analysis. J Neurosci. 2008 May 7; 28 (19) :4841-3. PubMed PMID:18463235.
  52. White P, Bishop F, Hardy H, Abdollahian S, White A, Park J, Kaptchuk TJ, Lewith GT. Southampton needle sensation questionnaire: development and validation of a measure to gauge acupuncture needle sensation. J Altern Complement Med. 2008 May; 14 (4) :373-9.
  53. Miller FG, Kaptchuk TJ. The power of context: reconceptualizing the placebo effect. J R Soc Med. 2008 May; 101 (5) :222-5.
  54. Chin Feman SP, Nguyen LT, Quilty MT, Kerr CE, Nam BH, Conboy LA, Singer JP, Park M, Lembo AJ, Kaptchuk TJ, Davis RB. Effectiveness of recruitment in clinical trials: an analysis of methods used in a trial for irritable bowel syndrome patients. Contemp Clin Trials. 2008 Mar; 29 (2) :241-51.
  55. Myers SS, Phillips RS, Davis RB, Cherkin DC, Legedza A, Kaptchuk TJ, Hrbek A, Buring JE, Post D, Connelly MT, Eisenberg DM. Patient expectations as predictors of outcome in patients with acute low back pain. J Gen Intern Med. 2008 Feb; 23 (2) :148-53.
  56. Kerr CE, Milne I, Kaptchuk TJ. William Cullen and a missing mind-body link in the early history of placebos. J R Soc Med. 2008 Feb; 101 (2) :89-92.
  57. Kirsch, I., Deacon, B. J., Huedo-Medina, T. B., Scoboria, A., Moore, T. J., & Johnson, B. T. (2008). Initial severity and antidepressant benefits: A meta-analysis of data submitted to the Food and Drug Administration. PLoS Medicine, 5(2).
  58. Whalley, B., Hyland, M.E., & Kirsch, I. Consistency of the placebo effect. Journal of Psychosomatic Research, 2008; 64, 537-541.
  59. Dorn SD, Kaptchuk TJ, Park JB, Nguyen LT, Canenguez K, Nam BH, Woods KB, Conboy LA, Stason WB, Lembo AJ. A meta-analysis of the placebo response in complementary and alternative medicine trials of irritable bowel syndrome. Neurogastroenterol Motil. 2007 Aug; 19 (8) :630-7.
  60. McManus CA, Schnyer RN, Kong J, Nguyen LT, Hyun Nam B, Goldman R, Stason WB, Kaptchuk TJ. Sham acupuncture devices–practical advice for researchers. Acupunct Med. 2007 Jun; 25 (1-2) :36-40.
  61. Lorber, W., Mazzoni, G., & Kirsch, I. Illness by Suggestion: Expectancy, Modeling, and Gender in the Production of Psychosomatic Symptoms. Annals of Behavioral Medicine 2007; 33, 112-116.
  62. Kong J, Kaptchuk TJ, Polich G, Kirsch I, Gollub RL. Placebo analgesia: findings from brain imaging studies and emerging hypotheses. Rev Neurosci. 2007; 18 (3-4) :173-90.
  63. Kirsch, I., & Moncrieff, J. (2007). Clinical trials and the response rate illusion. Contemporary Clinical Trials, 28 (4), 348-351.
  64. Wasan AD, Kaptchuk TJ, Davar G, Jamison RN. The association between psychopathology and placebo analgesia in patients with discogenic low back pain. Pain Med. 2006 May-Jun; 7 (3) :217-28.
  65. Conboy LA, Wasserman RH, Jacobson EE, Davis RB, Legedza AT, Park M, Rivers AL, Morey EB, Nam BH, Lasagna L, Kirsch I, Lembo AJ, Kaptchuk TJ, Kerr CE. Investigating placebo effects in irritable bowel syndrome: a novel research design. Contemp Clin Trials. 2006 Apr; 27 (2) :123-34.
  66. Kaptchuk TJ, Stason WB, Davis RB, Legedza AR, Schnyer RN, Kerr CE, Stone DA, Nam BH, Kirsch I, Goldman RH. Sham device v inert pill: randomised controlled trial of two placebo treatments. BMJ. 2006 Feb 18; 332 (7538) :391-7.
  67. Kong J, Gollub RL, Rosman IS, Webb JM, Vangel MG, Kirsch I, Kaptchuk TJ. Brain activity associated with expectancy-enhanced placebo analgesia as measured by functional magnetic resonance imaging. J Neurosci. 2006 Jan 11; 26 (2) :381-8.
  68. Wayne PM, Krebs DE, Macklin EA, Schnyer R, Kaptchuk TJ, Parker SW, Scarborough DM, McGibbon CA, Schaechter JD, Stein J, Stason WB. Acupuncture for upper-extremity rehabilitation in chronic stroke: a randomized sham-controlled study. Arch Phys Med Rehabil. 2005 Dec; 86 (12) :2248-55.
  69. Patel SM, Stason WB, Legedza A, Ock SM, Kaptchuk TJ, Conboy L, Canenguez K, Park JK, Kelly E, Jacobson E, Kerr CE, Lembo AJ. The placebo effect in irritable bowel syndrome trials: a meta-analysis. Neurogastroenterol Motil. 2005 Jun; 17 (3) :332-40.
  70. Lang EV, Hatsiopoulou O, Koch T, Berbaum K, Lutgendorf S, Kettenmann E, Logan H, Kaptchuk TJ. Can words hurt? Patient-provider interactions during invasive procedures. Pain. 2005 Mar; 114 (1-2) :303-9.
  71. Stone DA, Kerr CE, Jacobson E, Conboy LA, Kaptchuk TJ. Patient expectations in placebo-controlled randomized clinical trials. J Eval Clin Pract. 2005 Feb; 11 (1) :77-84.
  72. Miller FG, Kaptchuk TJ. Sham procedures and the ethics of clinical trials. J R Soc Med. 2004 Dec; 97 (12) :576-8.
  73. Kaptchuk TJ, Kerr CE.  Unbiased divination, unbiased evidence, and the patulin clinical trial. Int J Epidemiol. 2004 Apr; 33 (2) :247-51.
  74. Kaptchuk TJ. Effect of interpretive bias on research evidence. BMJ. 2003 Jun 28; 326 (7404) :1453-5.
  75. Kaptchuk TJ, Berman BM, Bausell RB. The placebo and complementary and alternative medicine: historical, scientific and methodological considerations. In: National Cancer Institute. Office of Cancer and Alternative Medicine. Expert Panels in Cancer CAM Research: Developing the State of the Science in Research Methodologies. Washington, D.C.: National Cancer Institute, 2003. p. 29-45.
  76. Di Blasi Z, Kaptchuk TJ, Weinman J, Kleijnen J. Informing participants of allocation to placebo at trial closure: postal survey. BMJ. 2002 Dec 7; 325 (7376) :1329.
  77. Kaptchuk TJ. The placebo effect in alternative medicine: can the performance of a healing ritual have clinical significance?. Ann Intern Med. 2002 Jun 4; 136 (11) :817-25.
  78. Kirsch, I., Moore, T. J., Scoboria, A., & Nicholls, S. S. (2002). The emperor’s new drugs: An analysis of antidepressant medication data submitted to the U.S. Food and Drug Administration. Prevention and Treatment, 5(23).
  79. Kaptchuk TJ. Is the placebo powerless?. N Engl J Med. 2001 Oct 25; 345 (17) :1277; author reply 1278-9.
  80. Kaptchuk TJ. The double-blind randomized controlled trial: gold standard or golden calf? J Clin Epidemiol 2001;54:541-49.
  81. Kaptchuk TJ. Debate over the history of placebos in medicine. [letter] Alt. Therapies 2000;18.
  82. Kaptchuk TJ. (book review) Shapiro A.: The powerful placebo: from ancient priests to modern physician. Bull Hist Med 1999; 73:159-60.
  83. Kirsch, I., & Sapirstein, G. (1998). Listening to Prozac but hearing placebo: A meta-analysis of antidepressant medication. Prevention and Treatment, 1 (Article 0002a).
  84. Kaptchuk TJ. Powerful placebo: the dark side of the randomized controlled trial. Lancet 1998a;351:1722-25.
  85. Kaptchuk TJ. Intentional ignorance: a history of blind assessment and placebo controls in medicine. Bull Hist Med 1998b; 72:389-433.
  86. Kaptchuk TJ. Concerns about run-in periods in randomized trials [letter]. J Amer Med Assoc 1998; 279:1526-1527.
  87. Kaptchuk TJ. Placebo needle for acupuncture [letter]. Lancet 1998; 352:634.
  88. Kaptchuk TJ, Edwards RA, Eisenberg DM. Complementary medicine—efficacy beyond the placebo effect. In: Ernst E, editor. Complementary medicine: an objective appraisal. Oxford, England: Butterworth Heinemann; 1996. p. 42-70.

  • Print
  • PDF
  • Facebook
  • Twitter
  • LinkedIn